What can be treated with stem cells /
What can stem cells do?
Stem cells are the maintainance team in the human body. Stem cells are quiet and inactive until they are activated. Only when a problem such as inflammation, injury, cell death etc. occurs do they become active and start to work. As soon as they are activated, they fulfil their tasks and multiply / divide and differentiate into the local and injured or diminished tissue. In the event of a skin injury, the activated stem cells begin, for example, to strengthen the partially damaged cells and replace the completely damaged cells. Stem cells are therefore crucial for the renewal of the skin.
Unfortunately, stem cells are not infinitely available in the different areas, so that an aging process becomes visible when the local stem cells run out or have been excessively consumed by inflammation / injury and healing / repair can no longer be achieved.
The idea of stem cell therapy is to shift the same mesenchymal stem cell type from areas of little or almost no use (in our case from the highly potent fatty tissue) to where it is needed due to ageing or injury.
There they unfold various mechanisms that are necessary for perfect healing and regeneration.
- inflammation inhibition:
Inflammations are defensive reactions of the immune system. Parts of the diseased tissue are often rejected during an inflammatory reaction. As inflammation progresses, entire tissues can be destroyed. The success of treatment depends on the early inhibition of inflammation, which up to now has always been treated with medication. Mesenchymal stem cells from the body’s own fat tissue form a particularly highly potent and successful alternative therapy WITHOUT side effects. The administered stem cells migrate to the inflammatory foci in the body and produce anti-inflammatory factors (cytokines) locally. This can positively influence inflammatory processes in the body, such as wound healing, and inflammatory signs of wear and tear in the musculoskeletal system, and make healing possible.
- Regeneration (cell renewal):
Damaged tissue can only recover to a limited extent.
Stem cells can multiply and develop into various tissue types (muscle, cartilage, tendon, bone, nerve or fat cells) and regenerate them.
Stem cell therapy is used to treat weak points in the body that cannot regenerate on their own or with the help of other treatments.
- No surgery and minimal swelling thanks to minimally invasive surgery.
- Reduction of the risk of infection due to lack of surgery and anti-infective mechanism of action of MSCs
- Regeneration of damaged tissue (skin, cartilage, tendons, intervertebral discs …)
- Complication-free, fast therapy (within one day)
- outpatient treatment possible
- faster healing
- Can be combined with surgery for faster healing
- Quick return to physical activities
Stem cells can always be used when tissue damage or inflammation is present. They are responsible for the regeneration and repair of body tissue so that body cells such as connective tissue, cartilage, tendons, heart, nerves and skin are regularly renewed and repaired.
If there is tissue damage that the body cannot reverse on its own or with the aid of other treatments, and if the local stem cells are too weak or no longer available in sufficient quantities, stem cell therapy supports the healing process by targeted administration of the body’s own stem cells from fat tissue (autologous mesenchymal stem cells).
Due to the strong anti-inflammatory and regenerative properties of the body’s own stem cells, stem cell therapy opens up great possibilities for medicine.
Stem cells have established themselves as a key element of regenerative medicine due to their ability to differentiate into a variety of different cell lines. In addition, their capacity for paracrine secretion of a wide range of cytokines, chemokines and growth factors makes them highly attractive for clinical application. Especially the anti-apoptotic (cell death), anti-inflammatory, vascular, immunomodulatory and scar-breaking effects make these cells very interesting for any kind of regenerative medicine.
Since adult mesenchymal divisive cells (stem cells) are the most promising cell types for cell-based therapies and are unused in fat, adipose tissue has become THE starting tissue for a rich and relatively easily accessible source of regenerative cell production. Hence the term ADSC: adipose derived stromal cells. ADSCs are multipotent and can differentiate into different cell types such as osteophytes (bones), chondrocytes (cartilage), adipocytes, neuronal cells (nerves), vascular endothelial cells (vascular cells), cardiomyocytes (heart cells), pancreatic β-cells and hepatocytes (liver cells). The additional secretion of trophic factors as well as their immunosuppressive properties and low immunogenicity maximizes the therapeutic and regenerative outcome in a wide range of applications and makes them highly relevant for clinical applications. Consequently, the therapeutic potential of ADSCs to virtually eliminate side effects is enormous and the application area is large:
Stem cells are always used when tissue damage or inflammation is present. They are responsible for the regeneration and repair of body tissue so that body cells such as connective tissue, cartilage, tendons, heart, nerves and skin are regularly renewed and repaired.
If there is tissue damage that the body cannot reverse on its own or with the aid of other treatments, and if the local stem cells are too weak or no longer available in sufficient quantities, stem cell therapy supports the healing process by targeted administration of the body’s own stem cells from fat tissue (autologous mesenchymal stem cells).
Due to the strong anti-inflammatory and regenerative properties of the body’s own stem cells, stem cell therapy opens up great possibilities for medicine.
Stem cells have established themselves as a key element of regenerative medicine due to their ability to differentiate into a variety of different cell lines. In addition, their capacity for paracrine secretion of a wide range of cytokines, chemokines and growth factors makes them highly attractive for clinical application. Especially the anti-apoptotic (cell death), anti-inflammatory, vascular, immunomodulatory and scar-breaking effects make these cells very interesting for any kind of regenerative medicine.
Since adult mesenchymal divisive cells (stem cells) are the most promising cell types for cell-based therapies and are unused in fat, adipose tissue has become THE starting tissue for a rich and relatively easily accessible source of regenerative cell production. Hence the term ADSC: adipose derived stromal cells. ADSCs are multipotent and can differentiate into different cell types such as osteophytes (bones), chondrocytes (cartilage), adipocytes, neuronal cells (nerves), vascular endothelial cells (vascular cells), cardiomyocytes (heart cells), pancreaticβ cells and hepatocytes (liver cells). The additional secretion of trophic factors as well as their immunosuppressive properties and low immunogenicity maximizes the therapeutic and regenerative outcome in a wide range of applications and makes them highly relevant for clinical applications. Consequently, the therapeutic potential of ADSCs to virtually eliminate side effects is enormous and the application area is large.
Prof. Dr. med. Philip Schoettle
KNEE AND HEALTH INSTITUTE
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